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 | Seeking Oral Care Solutions with Seal and Protect Benefit |
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Products, technologies or ingredients that (a) provide a layer, barrier or coating which will inhibit the formation of plaque or biofilm on tooth surfaces and/or (b) provide a coating to protect the teeth from stain and erosive acids or deliver effective amounts of oral care ingredient for an extended period of time. |
 | Seeking Next-Generation Equipment and Processing Technologies for Tempura Batter-Coated Fish Products |
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Nomad Foods is seeking innovative equipment, processing technologies, or integrated solutions that enable the development of next-generation tempura batter-coated fish products. By “conventional” battering and coating systems, we mean standard waterfall/curtain batter application combined with static frying or baking, which limits coating uniformity, consistency, and yield at scale. We are looking for solutions that demonstrably improve on this baseline by delivering: a more even and well-adhered batter coating across irregular fish portions, reduced batter loss/waste during application, and greater batch-to-batch consistency of coating weight and texture. We expect proposals exclusively from commercial technology providers — equipment manufacturers, engineering firms, technology start-ups, and system integrators with deployable or near-deployable solutions. Academic institutions or research groups without a commercial product, prototype, or industrial partner are not the focus of this call. By “improve robustness” we mean equipment and processes that maintain consistent coating performance despite normal variability in raw material (fish portion size and shape), batter viscosity, and line speed, with minimal downtime or operator intervention. By “flexibility for integration” we mean compatibility with our existing battering/coating and freezing lines: solutions that can be retrofitted or integrated without requiring a full line replacement, and that can accommodate multiple product formats (fillets, portions, nuggets) on the same equipment. |
| | Seeking Grooming Solutions |
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Grooming technology solutions that remove, trim, shape or style hair from the body and face, in safe, convenient ways that are achievable at home. |
 | Histone Deacetylases (HDAC) Targeted Libraries. Screening compounds for epigenetic drug discovery. |
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The design of selective #HDACs inhibitors requires more exploration due to the multifunctional mechanistic nature of cancer and still remains a great challenge. Dedicating to this promising class of epigenetic anti-cancer drug targets, HDACs Targeted Library (https://bit.ly/3xdJLWw) were kindly prepared by Otava scientists. |
 | NSG prolactin humanized mouse model to evaluate therapeutic strategies of ER+ breast cancer |
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Researchers at Georgetown University and the University of Nebraska have developed a humanized mouse model expressing the human prolactin gene, to better study ER+ breast cancer. Current models do not properly represent the hormonal environment seen in patients. Furthermore, mouse prolactin fails to activate human prolactin receptors in xenograft experiments, ultimately selecting for prolactin-independent tumor growth and differentiation. This model overcomes these limitations by replacing the mouse prolactin gene, with a knock-in of human prolactin, therefore mimicking the hormonal environment of breast cancer patients. Crossing these mice with immunodeficient strains, allows for human cell transplantation and engraftments to reliably study ER+ breast cancer. BACKGROUND High levels of circulating prolactin have been associated with an increased risk of breast cancer. Together with ER and PR, prolactin plays a crucial role in breast development, influencing both mammary cell proliferation and differentiation. Although prolactin receptors are expressed in the majority of breast cancers, current mouse models fail to account for the hormonal environment seen in patients. In these models, human prolactin is not sufficient to activate mouse prolactin receptors, while mouse prolactin acts as an antagonist to the human prolactin receptor. The NSG-Pro mouse overcomes these issues by expressing the human prolactin gene allowing for physiological levels of circulating human prolactin, and therefore more reliable assessments of disease progression and drug response. |
 | Actively-Controlled Morphing Wing Adaptive Skin for Enhanced Aircraft Control and Performance |
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To meet the ever increasing demand for more efficient, robust, and cost effective aircraft wing designs, conventional control surface methodologies need to be replaced by “morphing” technologies. Brunel University has developed a viable and realistic active wing/blade twist technology with an adaptive skin for seamless and adjustable changes in wing/blade twist angle. The technology is the ability to maintain a rigid skin with a low drag (smooth surface finish) despite high twist deformation during operation. Moreover, the structure is lightweight, and strong enough to carry aerodynamic loads. |
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